About The VALOR Lyme Disease Vaccine Study

Lyme disease is a common illness caused by a bacteria found in ticks. Bites from infected ticks can transfer the bacteria to humans and cause rashes, fever, and fatigue. If left untreated, Lyme disease can progress to cause severe, sometimes permanent symptoms. Currently, there are no approved vaccines available to prevent Lyme disease.

The VALOR study is an ongoing clinical trial which has already enrolled more than 6,000 adults and 800 children. This study is evaluating if an investigational Lyme vaccine is safe and effective for preventing Lyme disease in people who have been exposed through tick bites.

Make an Important Contribution

By choosing to volunteer for this study, participants could receive an investigational vaccine that may help to prevent Lyme disease. Participants will represent others like them — in age, gender, race, ethnicity, and from communities like their own. Including people from different backgrounds will help us develop a Lyme disease vaccine that is more likely to be effective for everyone.

Joining a clinical trial is an important and personal decision for you and your family. Thank you for considering this study.

Who Can Participate

Healthy adults and children 5 years of age or older who live in or often visit outdoor areas that may expose them to ticks may be eligible to participate. Study participants cannot have been diagnosed with Lyme disease within 3 months of enrollment.

Activities that may increase a person's risk of Lyme disease include:

Living in or frequently visiting areas where ticks that carry Lyme disease are found, such as wooded areas, tree lines, open fields, lakesides, or riversides

Having an outdoor occupation such as landscaping, forestry, wildlife, or parks management

Engaging in outdoor recreation such as hiking, camping, fishing, hunting, or gardening

Owning a pet that has returned with ticks attached after being outside

There are other requirements to participate in this study. A study team member will help determine if this study is a good fit for you.

What To Expect

Participants will be randomly assigned to receive the study vaccine or a placebo (shot with no active ingredient). Participants and the study doctor will not know which has been assigned.

This study will last about 2 and a half years. During this time, participants will have at least 7 in-clinic study visits, including 5 visits with blood draws.

Over the course of the study, participants will need to report any changes in their health to the study team.

There is no cost to participate, and health insurance is not needed to take part in this study. Participants will also be compensated for their time and travel.

Research studies are voluntary, and taking part in a research study is a personal choice. Participants may leave the study at any time, for any reason.

Before You Continue...

A first step as you consider this study is to answer a 5-minute online questionnaire about your health and medical history. If your answers show the study might be a good fit, you may choose to be referred to a study clinic that you select. You will then be asked to provide your contact information for a study representative to contact you and discuss the next steps. Only the study staff can determine if you meet the study's eligibility criteria and are able to enroll in the study.

Click 'Next' to begin the questionnaire.

Question 1 of 4

A parent or guardian should answer the question below for children 5 to 17 years old (if applicable).

Do you live in an area where ticks are found and/or do you regularly participate in outdoor activities that put you at risk for tick bites?

Question 2 of 4

A parent or guardian should answer the question below for children 5 to 17 years old (if applicable).

Do you take any medications that suppress your immune system?

Question 3 of 4

A parent or guardian should answer the question below for children 5 to 17 years old (if applicable).

Are you currently pregnant or breastfeeding?

Question 4 of 4

A parent or guardian should answer the question below for children 5 to 17 years old (if applicable).

Have you been diagnosed with or treated for Lyme disease in the past 3 months?

Thank you for your interest in our Lyme disease vaccine study and for answering our questions.

There may be other Pfizer research studies enrolling in your area in the future. If you would like to be notified about future research opportunities, we will collect your name, phone number, and email address so that a study representative may contact you about other research studies. Your contact information will not be used for any other purposes.

The individual responses you've provided will be used by Pfizer, or our partners supporting this study, to look for areas of improvement such as revising the criteria for participation in this study. Pfizer study team members and our partners will have access to reports containing aggregated data that will not be directly linked back to you. All information is stored on servers in the United States.

So far — So good!

Please enter your information below to find a study location near you. By submitting this form, you confirm that you are at least 18 years of age (or the legal age of consent in your state if it is over 18) and that Pfizer or our partners may contact you about information related to research studies enrolling in your area. Once you select a site, the research study staff will contact you to see if you qualify to enroll.

Choose a Location

Please select a research site near you. This list displays sites located up to 40 miles away from the address you entered. If you don't see a site near you, then select "The sites listed here are not convenient for me." Study locations are being added regularly. A study representative will call you if a research site becomes available in your area.

The sites listed here are not convenient for me.

We're sorry, but you are not eligible at this time...

Please enter your information below if you would like to be contacted about future clinical research opportunities. By submitting this form, you confirm that you are at least 18 years of age (or the legal age of consent in your state if it is over 18) and that Pfizer or our partners may contact you about information related to research studies enrolling in your area.